The 1918 flu epidemic was probably the deadliest plague in human history, killing more than 50 million people worldwide. Now it appears that a small number of the deaths may have been caused not by the virus, but by a drug used to treat it: aspirin.
... many factors that might have influenced the outcome in any particular case, Dr. Starko wrote, aspirin overdose stands out for several reasons, including a confluence of historical events...Aspirin packages were produced containing no warnings about toxicity and few instructions about use. In the fall of 1918, facing a widespread deadly disease with no known cure, the surgeon general and the United States Navy recommended aspirin as a symptomatic treatment, and the military bought large quantities of the drug.
The Journal of the American Medical Association suggested a dose of 1,000 milligrams every three hours, the equivalent of almost 25 standard 325-milligram aspirin tablets in 24 hours. This is about twice the daily dosage generally considered safe today.
The pharmacology of aspirin is complex and was not fully understood until the 1960s, but dosage is crucial. Doubling the dose given at six-hour intervals can cause a 400 percent increase in the amount of the medicine that remains in the body. Even quite low daily doses — six to nine standard aspirin pills a day for several days — can lead to dangerously high blood levels of the drug in some people. Read full from New York Times, via cbgnetwork