Nearly half of all children who die are in five countries: Nigeria, Congo, India, Pakistan and China, it said in a report.
"Progress can and must be made," said Anthony Lake, UNICEF's executive director. "When concerted action, sound strategies, adequate resources and strong political will are harnessed in support of child and maternal survival, dramatic reductions in child mortality aren't just feasible, they are morally imperative."
The top killers are malaria, pneumonia and diarrhea, the report said, taking the lives of about 6,000 children under age 5 daily. A lack of nutrition contributes to almost half of these deaths, the U.N. said.
Eastern and Southern Africa have reduced their death rates for children under 5 by more than 50 percent since 1990. West and Central Africa are the only regions not to have at least halved the number of children under 5 dying over the past 22 years, the U.N. said.
Nigeria bears more than 30 percent of early childhood deaths for malaria and 20 percent of the deaths associated with HIV. Globally, the country accounts for one in every eight child deaths, the U.N. said.
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