The worldwide obesity epidemic is usually blamed  on overeating and under exercising. But limited evidence has suggested a few  environmental contaminants may also be playing a role. Now some of the first  detailed evidence implicating organotins, a class of persistent compounds  containing at least one tincarbon bond, has been published in the September  2006 Molecular Endocrinology. A team of U.S. and Japanese researchers  found both in vitro and in vivo evidence that exposure to a number  of organotins, at concentrations typically found in people and wildlife, can  contribute to alterations in pathways known to play a key role in excess weight  gain, and can lead to significant aberrations in fat cells in mice and frogs.  
 The percentage Americans who are overweight  and obese has been rising sharply in the past 30 years or so. Excess weight is  strongly linked with many serious health problems, including heart disease, type  2 diabetes, high blood pressure, and some cancers. Prevention of obesity is by  far the best available treatment. Preventing exposures to environmental  contaminants over the course of a lifetime, even prior to conception, may be an  important part of the battle, if this and other recent papers hold up to  scrutiny.
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