At the U.S. Army's request the National Research Council (NRC) established the Committee to Review Risk Assessment Approaches for the Medical Countermeasures Test and Evaluation (MCMT&E) facility at Fort Detrick, in Frederick, Maryland. The committee was charged with reviewing a proposed approach to preparing a risk assessment for the new biocontainment laboratory at the base. Review of Risk Assessment Work Plan for the Medical Countermeasures Test and Evaluation Facility is the second letter report on the Army contractor's proposed work plan for conducting the risk assessment.