Dec 27, 2009

Microbes That Keep Us Healthy Starting To Die Off

Scientific American: "The human body has some 10 trillion human cells—but 10 times that number of microbial cells. So what happens when such an important part of our bodies goes missing? With rapid changes in sanitation, medicine and lifestyle in the past century, some of these indigenous species are facing decline, displacement and possibly even extinction. In many of the world's larger ecosystems, scientists can predict what might happen when one of the central species is lost, but in the human microbial environment—which is still largely uncharacterized—most of these rapid changes are not yet understood. 'This is the next frontier and has real significance for human health, public health and medicine,' says Betsy Foxman, a professor of epidemiology at the University of Michigan School of Public Health in Ann Arbor. Meanwhile, each new generation in developed countries comes into the world with fewer of these native populations. 'They're actually missing some component of their microbiota that they've evolved to have,' Foxman says."

Related? exposure to everyday germs may protect kids from disease as adults
The study, published in the December 9th edition of the journal Proceedings of the Royal Society B: Biological Sciences, is the first to investigate whether microbial exposures early in life affect inflammatory processes related to diseases in adulthood. Remarkably, the Northwestern study suggests exposure to infectious microbes in childhood may actually protect youngsters from developing serious illnesses, including cardiovascular diseases, when they grow into adults.

"Contrary to assumptions related to earlier studies, our research suggests that ultra-clean, ultra-hygienic environments early in life may contribute to higher levels of inflammation as an adult, which in turn increases risks for a wide range of diseases," Thomas McDade, lead author of the study, said in a statement to the media. McDade is associate professor of anthropology in Northwestern's Weinberg College of Arts and Sciences and a faculty fellow at the Institute for Policy Research.

He added that humans have only recently lived in super clean environments and it could well be time to put down the antibacterial soap. That's because the new research suggests that inflammatory systems need a reasonably high level of exposure to common everyday germs and other microbes to develop and work properly in the body.

"In other words, inflammatory networks may need the same type of microbial exposures early in life that have been part of the human environment for all of our evolutionary history to function optimally in adulthood," stated McDade.
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