Below is an excerpt from: https://www.federalregister.gov/articles/2013/06/28/2013-15523/availability-of-draft-toxicological-profiles
This notice announces the availability of Set 25 Toxicological Profiles for review and comment. Comments can include additional information or reports on studies about the health effects of Set 25 substances. Although ATSDR considered key studies for each of these substances during the profile development process, this Federal Registernotice solicits any relevant, additional studies, particularly unpublished data. ATSDR will evaluate the quality and relevance of such data or studies for possible inclusion in the profile. ATSDR remains committed to providing a public comment period for this document as a means to best serve public health and our clients. The Set 25 Toxicological Profile is available online at http://www.atsdr.cdc.gov/toxprofiles/index.asp and www.regulations.gov,docket ATSDR-2013-0001.
The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), § 104(i)(3), [42 U.S.C. 9604(i)(3)], directs the ATSDR administrator to prepare toxicological profiles of priority hazardous substances and, as necessary, to revise and publish each updated toxicological profile.
The Superfund Amendments and Reauthorization Act (SARA) (99) amends the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund) (42 U.S.C. 9601 et seq.) by establishing certain responsibilities for ATSDR and the U.S. Environmental Protection Agency (U.S. EPA) with regard to hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL). As part of these responsibilities, the ATSDR administrator must prepare toxicological profiles for substances enumerated on the priority list of hazardous substances. This list identifies 275 hazardous substances which, according to ATSDR and U.S. EPA, pose the most significant potential threat to human health. The availability of the revised priority list of 275 hazardous substances was announced in the Federal Register on March 6, 2008 (73 FR 12178). In addition, ATSDR has the authority to prepare toxicological profiles for substances not found at sites on the National Priorities List, in an effort to ". . . establish and maintain inventory of literature, research, and studies on the health effects of toxic substances" under CERCLA Section 104(i)(1)(B). This is also to respond to requests for consultation under section 104(i)(4), and as otherwise necessary to support the site-specific response actions conducted by ATSDR.
Each profile will include an examination, a summary, and an interpretation of available toxicological information and epidemiological evaluations. This information and these data identify the levels of significant human exposure for the substance and for the associated health effects. The profiles must also include a determination of whether adequate information on the health effects of each substance is available or is in the process of development. If adequate information is not available, ATSDR, in cooperation with the National Toxicology Program (NTP), is required to ensure the initiation of a program of research to determine such health effects.
All toxicological profiles issued as "Drafts for Public Comment" represent ATSDR's best efforts to provide important toxicological information on priority hazardous substances.
Set 25 toxicological profiles:
| Name | CAS | |
|---|---|---|
| 1 | Hexachlorobenzene (UPDATE) | 118-74-1 |
| 2 | Endosulfan (UPDATE) | 115-29-7 |
| Endosulfan sulfate | 1031-07-8 | |
| Endosulfan-alpha | 95-99-98 | |
| Endosulfan-beta | 33213-65-9 | |
| 3 | 1,1-Dichloroethane (UPDATE) | 75-34-3 |
| 4 | Dinitrotoluenes (DNT) (UPDATE) | |
| 2,3-DNT | 602-01-7 | |
| 2,4-DNT | 121-14-2 | |
| 2,5-DNT | 619-15-8 | |
| 2,6-DNT | 606-20-2 | |
| 3,4-DNT | 610-39-9 | |
| 3,5-DNT | 618-85-9 |
